Product Parameters

Product Introduction 

Ebselen is a small-molecule organoselenium compound with well-characterized redox-modulating properties. It exhibits glutathione peroxidase (GPx)-like activity and has demonstrated the ability to react with peroxides and peroxynitrite, supporting its potential role in studies of oxidative stress and cellular redox regulation. In experimental systems, Ebselen has been investigated for its antioxidant and anti-inflammatory activities, including the modulation of lipid peroxidation and several redox-sensitive enzymes and signaling pathways. Its reported biological effects also include inhibition of cyclooxygenase activity, lipoxygenase activity, and other thiol-dependent targets. Beyond its redox activity, Ebselen has been studied for potential neuroprotective effects in models of acute ischemic injury and oxidative stress. Research has also explored its antibacterial activity, including activity against multidrug-resistant Staphylococcus aureus (MRSA), as well as its interactions with viral and cellular targets. With its low molecular weight, cell permeability, and broad range of experimentally characterized biological activities, Ebselen is a versatile research compound for investigations involving oxidative stress, redox biology, inflammation, AIDS, neuroprotection, and cellular signaling.

Features

(1) GPx-like antioxidant activity: Ebselen exhibits glutathione peroxidase (GPx)-like activity and supports the body’s antioxidant defense through peroxide reduction and cellular redox regulation.

(2) Potent Redox-Modulating activity: It reacts with peroxides and peroxynitrite, and  interacts with thiol-containing proteins, contributing to the regulation of oxidative stress and lipid peroxidation.

(3) Broad biological activity: Ebselen interacts with multiple redox- and inflammation-related targets, including cyclooxygenase, lipoxygenase, and the thioredoxin reductase system, supporting a broad range of biological effects.

(4) Small molecule with high cell permeability: Its low molecular weight and cell-permeable properties support efficient access to intracellular targets and make it well suited to applications requiring cellular activity.

(5) Good solubility in organic solvents: Ebselen is soluble in commonly used organic solvents, including DMSO, ethanol, methanol, acetone, and acetonitrile, offering flexibility for formulation and preparation.

Applications

Ebselen combines glutathione peroxidase (GPx)-like activity with broad redox-regulating properties, supporting its relevance across several areas of nutritional and functional health development.

1. Antioxidant & Healthy Aging Support
   Ebselen exhibits GPx-like activity and participates in peroxide reduction and redox regulation, with relevance to oxidative stress and lipid peroxidation. These properties support its positioning in antioxidant nutrition and healthy aging, including applications related to skin health and environmental oxidative stress.
2. Inflammation & Joint Health
   Ebselen interacts with multiple pathways involved in oxidative and inflammatory processes, including cyclooxygenase, lipoxygenase, and the thioredoxin reductase system. Its combined antioxidant and inflammation-modulating activities make it relevant to nutritional approaches focused on inflammatory balance and joint health.
3. Metabolic Health & Insulin Sensitivity
   Ebselen has been identified as an inhibitor of SHIP2, a negative regulator of insulin signaling. Preclinical studies have associated SHIP2 inhibition by ebselen with enhanced Akt signaling and glucose uptake, together with improvements in insulin sensitivity and reductions in oxidative stress and inflammatory responses. These findings support continued interest in ebselen for metabolic health and glucose-regulation research.
4. Auditory & Neurological Health
   Ebselen has been investigated for its antioxidant, inflammation-modulating, and neuroprotective activities in auditory and neurological health. Research has examined its potential in noise- and drug-induced auditory injury, as well as oxidative and ischemic neuronal injury. Its auditory-health research has also progressed into clinical development, providing a broader scientific basis for continued investigation in this area.